Novedades 

DFBMC + IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires, Argentina.

Regulación del splicing alternativo del RNA mensajero

Trabajos seleccionados

Para una lista completa de publicaciones ver PubMed

- Muñoz*, M. J., Nieto Moreno*, N., Giono*, L. E., Cambindo Botto, A. E., Dujardin, G., Bastianello, G., Lavore, S., Torres-Méndez, A., Menck, C. F. M., Blencowe, B., Irimia, M., Foiani, M. & Kornblihtt, A. R.

Major roles of cyclobutane pyrimidine dimers, nucleotide excision repair and ATR in the alternative splicing response to UV irradiation.

Cell Reports (2017) 12, 2868-2879.

- Fiszbein, A., Giono, L.E., Quaglino, A., Berardino, B. G., Singaut, L., von Bildering, C., Schor, I. E., Pietrasanta, L., Caramelo, J., Srebrow, A. & Kornblihtt, A. R.

Alternative splicing of G9a regulates neuronal differentiation

Cell Reports (2016) 14, 2797–2808

- Agirre*, E., Bellora*, N., Alló*, M., Pagès, A., Bertucci, P., Kornblihtt, A. R. & Eyras, E.

A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins

BMC Biology (2015) 13, 31

- Buggiano, V., Petrillo, E., Alló, M., Lafaille, C., Redal, M. A., Alghamdi, M. A., Khoder, M. I., Shamy, M., Muñoz, M. & Kornblihtt, A. R.

Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells

Environmental Research (2015) 140, 185-190

- Alló*, M., Agirre*, E., Bessonov*, S., Bertucci*, P., Gómez Acuña*, L., Buggiano, V., Bellora, N., Singh, B., Petrillo, E., Blaustein, M., Miñana, B., Dujardin, G., Pozzi, B., Pelisch, F., Bechara, E., Agafonov, D. E., Srebrow, A., Lührmann, R., Valcárcel, J., Eyras, E.* & Kornblihtt, A. R.*

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells

Proc. Natl. Acad. Sci. USA (2014) 111, 15622-15629.

- Petrillo, E., Godoy Herz, M. A., Simpson, C., Fuller, J., Yanovsky, M. J., Fuchs, A., Brown, J. W. S., Barta, A., Kalyna, M. & Kornblihtt, A. R.

A chloroplast retrograde signal regulates nuclear alternative splicing

Science (2014) 344, 427-430

- Dujardin, G., Lafaille, C., de la Mata, M., Marasco, L., Muñoz, M. J., Le Jossic-Corcos, C., Corcos, L. & Kornblihtt, A. R.

How slow RNA Polymerase II elongation favors alternative exon skipping

Molecular Cell (2014) 54, 683-690

- Bielli, P., Busà, R., Di Stasi, S. M., Muñoz, M. J., Botti, F., Kornblihtt, A. R. & Sette C.

The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis.

EMBO Reports (2014) 15, 419-427

- Schor, I. E., Fiszbein, A., Petrillo, E. & Kornblihtt, A. R.

Intragenic epigenetic changes modulate NCAM alternative splicing upon neuronal differentiation

EMBO J. (2013) 32, 2264-2274

- Schor, I. E., Llerès, D., Risso, G., Pawellek, A., Ule, J., Lamond, A. & Kornblihtt, A. R.

Perturbation of chromatin structure globally affects localization and recruitment of splicing factors

PLoSOne (2012) 7, e48084

- de la Mata, M., Lafaille, C. & Kornblihtt, A. R.

First come, first served revisited: factors affecting the same alternative splicing event have different effects on the relative rates of intron removal.

RNA (2010) 16, 905-912

- Sánchez*, S. E., Petrillo*, E., Beckwith, E. J., Zhang, X., Matías, L., Rugnone, C., Hernando, E., Cuevas, J. C., Godoy Herz, M. A., De Petris-Chauvin, A., Simpson, C. G., Brown, J. W. S., Cerdán, P. D., Borevitz, J. O., Mas, P., Ceriani, M. F., Kornblihtt, A. R. & Yanovsky, M. J.

A methyl transferase links the circadian clock to the regulation of transcription and alternative splicing.

Nature (2010) 468, 112-116

- Muñoz, M. J., Pérez Santangelo, M. S., Paronetto, M. P., de la Mata, M., Pelisch, F., Boireau, S., Glover-Cutter, K., Ben-Dov, C., Blaustein, M., Lozano, J. J., Bird, G., Bentley, D., Bertrand, E. & Kornblihtt, A. R.

DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

Cell (2009) 137, 708-720. Commented as Leading Edge in Cell 137, 600-602 (2009)

- Schor, I. E., Rascovan, N., Pelisch, F., Alló, M. & Kornblihtt, A. R.

Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing.

Proc. Natl. Acad. Sci. USA. (2009) 106, 4325-4330

- Alló, M., Buggiano, V., Fededa, J. P., Petrillo, E., Schor, I., de la Mata, M., Agirre, E., Plass, M., Eyras, E., Abou Elela, S., Klinck, R., Chabot, B. & Kornblihtt, A. R.

Control of alternative splicing through siRNA-mediated transcriptional gene silencing.

Nature Struct. Mol. Biol. (2009) 16, 717-724

- de la Mata, M. & Kornblihtt, A. R.

RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.

Nature Struct. Mol. Biol. (2006) 13, 973-980 (Commented as News and Views in Nature Struct. Mol. Biol. 13, 952-953, 2006. Selected in Faculty of 1000).

- Fededa, J. P., Petrillo, E., Gelfand, M. S., Neverov, A. D., Kadener, S., Nogués, G., Pelisch, F., Baralle, F. E., Muro, A. F., and Kornblihtt, A. R.

A polar mechanism coordinates different regions of alternative splicing within a single gene.

Molecular Cell (2005) 19, 393-404

- de la Mata, M., Alonso, C. R., Kadener, S., Fededa, J. P., Blaustein, M., Pelisch, F., Cramer, P., Bentley, D., & Kornblihtt, A. R.

A slow RNA polymerase II affects alternative splicing in vivo.

Molecular Cell (2003) 12, 525-532 (Commented as News and Views in Nature Struct. Mol. Biol. 10, 876-878 (2003). Selected as “exceptional” (factor 9) in Fac)

- Kadener, S., Fededa, J. P., Rosbash, M. & Kornblihtt, A. R.

Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation.

Proc. Natl. Acad. Sci. USA (2002) 99, 8185-8190 (Selected as “must read” (factor 3) in Faculty of 1000).

- Kadener, S., Cramer, P., Nogués, G., Cazalla, D., de la Mata, M., Fededa, J. P., Werbajh, S., Srebrow, A. & Kornblihtt, A. R.

Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing.

EMBO J. (2001) 20, 5759-5768

- Cramer, P., Cáceres, J., Cazalla, D., Kadener, S., Muro, A. F., Baralle, F. E. & Kornblihtt, A. R.

Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer.

Molecular Cell (1999) 4, 251-258

- Melen, G. J., Pesce, C. G., Rossi, M. S. & Kornblihtt, A. R.

Novel processing in a mammalian nuclear 28S pre-rRNA: tissue-specific elimination of an "intron" bearing a hidden break site.

EMBO J. (1999) 18, 3107-3118

- Cramer, P., Pesce, C. G., Baralle, F. E. & Kornblihtt, A. R.

Functional association between promoter architecture and transcript alternative splicing.

Proc. Natl. Acad. Sci. USA (1997) 94,, 11456-11460

- Alonso, C. R., Pesce, C. G. & Kornblihtt, A. R.

The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene.

J. Biol. Chem. (1996) 271, 22271-22279

- Lavigueur, A., La Branche, H., Kornblihtt, A. R. & Chabot, B.

A splicing enhancer in the human fibronectin alternate ED1 exon stimulates the binding of U2AF65 and U2 snRNP.

Genes & Dev. (1993) 7, 2405-2417

- Muro, A. F., Bernath, V. A. & Kornblihtt, A. R.

Interaction of the -170 Cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter.

J. Biol. Chem. (1992) 267, 12767-12774

- Bernath, V. A., Muro, A. F., Vitullo, A. D., Bley, M. A., Barañao, J. L. & Kornblihtt, A. R.

Cyclic AMP inhibits fibronectin gene expression in a newly developed granulosa cell line by a mechanism that suppresses cAMP-responsive-element transcriptional activation.

J. Biol. Chem. (1990) 265, 18219-18226

- Gutman, A. & Kornblihtt, A. R.

Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA.

Proc. Natl. Acad. Sci. USA (1987) 84, 7179-7182

- Kornblihtt, A. R., Umezawa, K., Vibe-Pedersen, K. & Baralle, F. E.

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

EMBO J. (1985) 4, 1755-1759

- Kornblihtt, A. R., Vibe-Pedersen, K. & Baralle, F. E.

Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain.

EMBO J. (1984) 3, 221-226

- Kornblihtt, A. R., Vibe-Pedersen, K. & Baralle, F. E.

Isolation and characterization of cDNA clones for human and bovine fibronectins.

Proc. Natl. Acad. Sci. USA (1983) 80, 3218-3222